@article {49275,
	title = {Strategies employing transition-metal free conditions for C-C bond formation in indoles},
	journal = {ChemistrySelect},
	volume = {9},
	year = {2024},
	month = {SEP},
	pages = {e202403280},
	type = {Review},
	abstract = {<p>
	Indole motifs are omnipresent in nature and can be found in many natural products as well as pharmaceuticals. It is for this reason synthetic transformations of indole have become a topic of interest for the organic and medicinal chemist community for decades. In this review, we have emphasized the functionalization of indoles via transition-metal-free approaches. This review touches on many aspects in different sub-sections, which gives a proposition of the tactics employed for the functionalization of indoles and an overview of the road ahead. In this review, essentially transition-metal-free conditions for C-C bond formation reactions in indoles has been explored. This review describes various approaches of functionalization at the C-2, C-3, C-4 and C-7 position of indoles which comprises arylation, alkenylation, acylation, formylation, alkylation, bisindolyl and cyclization strategies. Also, strategies incorporating N-alkylation/arylation has also been covered. image</p>
},
	keywords = {Alkylation, Arylation, formylation, Indole, transition-metal free},
	issn = {2365-6549},
	doi = {10.1002/slct.202403280},
	author = {Ghodake, Balaji M. and Paul, Sayantan and Bhattacharya, Asish K.}
}
@article {49510,
	title = {Catalyst and transition-metal free 1,6-conjugate addition of azobisisobutyronitrile: access to isobutyronitrile containing diarylmethanes},
	journal = {Organic \& Biomolecular Chemistry},
	volume = {23},
	year = {2025},
	month = {APR},
	pages = {3956-3966},
	type = {Article},
	abstract = {<p>
	A catalyst and transition-metal free 1,6-conjugate addition of azobisisobutyronitrile to para-quinone methides for the synthesis of isobutyronitrile containing diarylmethanes has been achieved. This protocol enables the synthesis of isobutyronitrile containing diarylmethanes in good yields and with a broad substrate scope. This is the first example wherein azobisisobutyronitrile has been used as a cyanide source for 1,6-conjugate addition under catalyst and metal-free conditions.</p>
},
	issn = {1477-0520},
	doi = {10.1039/d5ob00012b},
	author = {Mamale, Ajay G. and Ghodake, Balaji M. and Gonnade, Rajesh G. and Bhattacharya, Asish K.}
}
