@article { ISI:000371117900016,
	title = {Bioresponsive carbon nano-gated multifunctional mesoporous silica for cancer theranostics},
	journal = {Nanoscale},
	volume = {8},
	number = {8},
	year = {2016},
	month = {DEC},
	pages = {4537-4546},
	publisher = {ROYAL SOC CHEMISTRY},
	address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND},
	abstract = {<p>Designing bioresponsive nanocarriers for controlled and efficient intracellular drug release for cancer therapy is a major thrust area in nanomedicine. With recent recognition by the US FDA as a safe material for human trials, mesoporous silica nanoparticles (MSNPs) are being extensively explored as promising theranostic agents. Green fluorescent carbon quantum dots (CQDs), though known as possible alternatives for their more toxic and relatively less efficient predecessors, are less known as gate keepers for drug release control. We report for the first time an efficient bioresponse of CQDs when judiciously designed using glutathione cleavable (redox responsive) disulphide bonds. When the anticancer drug doxorubicin loaded MSNPs are capped with these CQDs, they display promising drug release control on exposure to a mimicked intracellular cancer environment. Their dual functionality is well established with good control on preventing the premature release and exceptional bio-imaging of HeLa cancer cells. Fluorescence images prove selective targeting of HeLa cells by overexpression of folate receptors from the surface functionalised folic acid ligand. Extensive characterisation using XRD, TEM, BET analysis, drug loading tests, drug release kinetics, MTT assay and fluoroscence cell imaging helps in understanding the multi-functionalities of the successful design, extending its scope with exciting prospects towards non-invasive targeted drug delivery and bio-imaging for effective cancer diagnosis and treatment.</p>},
	issn = {2040-3364},
	doi = {10.1039/c5nr06756a},
	author = {Prasad, Rajendra and Aiyer, Sandhya and Chauhan, Deepak S. and Srivastava, Rohit and Selvaraj, Kaliaperumal}
}
@article {45647,
	title = {Fluorescent carbon nanodots for targeted in vitro cancer cell imaging},
	journal = {Applied Materials Today},
	volume = {4},
	year = {2016},
	month = {SEP},
	pages = {71-77},
	type = {Article},
	abstract = {<p>Carbon quantum dots (CQDs or C-dots, \&lt;= 10nm in size) are tiny carbon nanoparticles being envisaged in biosensing, bio-imaging and biomolecular/drug delivery. In the present investigation, green fluorescent carbon quantum/nano dots (GCQDs, similar to 3 nm in size) were synthesized through facile chemical slicing method. Further, folic acid (FA) functionalized GCQDs (GCQDs-FA) were obtained to enhance their targeting ability. FA is known to positively influence the binding potential and penetration into the cancer cells because of high abundance of folate receptors (FR) on various cancer cell membranes. We report high biocompatibility, photoluminescence stability and excellent in vitro cancer cell cytoplasm and nucleus targeting performance of GCQDs-FA on MCF-7 breast cancer cells. (C) 2016 Elsevier Ltd. All rights reserved.</p>},
	keywords = {Cancer cell bio-imaging, Carbon quantum/nano dots, Cell cytoplasm and nucleus targeting, Green fluorescence, Photoluminescence stability, Targeting ability},
	issn = {2352-9407},
	doi = {10.1016/j.apmt.2016.07.001},
	author = {Aiyer, Sandhya and Prasad, Rajendra and Kumar, Manoj and Niryikar, K. and Jain, Bhanprakash and Kushwaha, Omkar S.}
}
@article {46423,
	title = {Fluorescent carbon nanodots for targeted in vitro cancer cell imaging (vol 4, pg 71, 2016)},
	journal = {Applied Materials Today},
	volume = {17},
	year = {2019},
	month = {DEC},
	pages = {236-240},
	type = {Correction},
	issn = {2352-9407},
	doi = {10.1016/j.apmt.2019.07.014},
	author = {Aiyer, Sandhya and Prasad, Rajendra and Kumar, Manoj and Nirvikar, K. and Jain, Bhanprakash and Kushwaha, Omkar S.}
}
