@article {50189,
	title = {Organocatalytic enantioselective desymmetrization cascade for the construction of functionalized oxabicyclo[3.3.1]nonanes},
	journal = {Organic Letters},
	volume = {28},
	year = {2026},
	month = {JUL },
	pages = {8271-8277},
	type = {Article},
	abstract = {<p>
	The construction of stereochemically enriched molecules from readily accessible meso and prochiral precursors via catalytic enantioselective desymmetrization represents a powerful synthetic strategy. Herein, we report an efficient enantioselective Michael/oxa-Michael cascade reaction between C4-functionalized meso-2,5-cyclohexadienones and beta-ketoesters, catalyzed by a Takemoto chiral squaramide. This protocol enables the efficient construction of densely functionalized oxabicyclo[3.3.1]nonane frameworks bearing two or three stereogenic centers, with good to excellent diastereo- and enantioselectivities. Furthermore, the method is amenable to scale-up and offers opportunities for late-stage functionalization.</p>
},
	issn = {1523-7060},
	doi = {10.1021/acs.orglett.6c01690},
	author = {Chavan, Vikas S. and Sahoo, Shubhranshu Shekhar and Gonnade, Rajesh G. and Kontham, Ravindar}
}
