@article {50178,
	title = {Rongalite-mediated hydride-free chemoselective reduction of the bond of isatin-derived Michael acceptors},
	journal = {Organic \& Biomolecular Chemistry},
	volume = {24},
	year = {2026},
	month = {JUN},
	pages = {5164-5170},
	type = {Article},
	abstract = {<p>
	A chemoselective and sustainable reduction of the CC bond in isatin-derived Michael acceptors has been achieved using rongalite as an inexpensive hydride-free reductant. The transformation proceeds efficiently in ethanol at room temperature with p-TSA as an additive, without the need for transition metals, external hydrides, visible light, or additional catalysts. Under these mild conditions, a wide range of substrates were converted to the corresponding reduced products in excellent yields, highlighting the broad applicability of the protocol. Mechanistic studies support a rongalite-mediated 1,4-conjugate addition pathway, which accounts for the observed high selectivity. The practicality and sustainability of the method are further validated by gram-scale synthesis. Furthermore, the protocol is compatible with bioactive isatin derivatives and the corresponding products serve as valuable intermediates for downstream transformations, including spirocyclization and dimerization reactions.</p>
},
	issn = {1477-0520},
	doi = {10.1039/d6ob00572a},
	author = {Chaudhari, Suryakant S. and Nichinde, Chandrakant B. and Patil, Baliram R. and Kinage, Anil K.}
}
