@article {50114,
	title = {Metal-free direct amidation of nitroarenes with carboxylic acids},
	journal = {Journal of Organic Chemistry},
	volume = {91},
	year = {2026},
	month = {MAY },
	pages = {5994-6006},
	type = {Article},
	abstract = {<p>
	We report a facile, metal-free protocol for the direct amidation of readily available nitroarenes and carboxylic acids. The method proceeds via in situ activation of carboxylic acids, nitro-to-amine reduction, and subsequent C-N coupling to furnish the corresponding amide bond. This transformation exhibits broad functional group tolerance and delivers the desired amides in high yields. The method{\textquoteright}s applicability is showcased through the efficient synthesis of pharmaceutically and agrochemically important amide scaffolds and rapid derivatization of drug molecules containing carboxylic acid groups.</p>
},
	issn = {0022-3263},
	doi = {10.1021/acs.joc.6c00299},
	author = {Akhade, Akshay M. and Handore, Kishor L.}
}
