@article {49977,
	title = {Graphene oxide-cyclopentylamine (GO-d-CP) liquid crystals as a novel alignment medium for anisotropic nmr with analyte recovery},
	journal = {Chemistry{\textemdash}Methods},
	volume = {5},
	year = {2025},
	month = {APR},
	pages = {e202400039},
	type = {Article},
	abstract = {<p>
	<span style="color: rgb(0, 0, 0); font-family: \&quot;Open Sans\&quot;, icomoon, sans-serif; font-size: 16px;">In this study, we present graphene oxide derivatized with cyclopentylamine (GO-d-CP) as a DMSO-compatible liquid crystal alignment medium that is free from any background NMR signal for application in anisotropic NMR. This novel alignment medium facilitates optimal isotropic and anisotropic conditions within a single sample preparation, controlled by sonication, thereby enabling the measurement of anisotropic NMR parameters- residual dipolar couplings (RDC) and residual chemical shift anisotropy (RCSA). GO-d-CP offers several advantages, including ease of synthesis, isolation of solid GO-d-CP as a stable non-hygroscopic material, and maintenance of the anisotropic state stability \&gt;30 days, allowing for prolonged and repetitive experiments. Notably, post the analysis it allows for easy recovery of valuable analytes as well as GO-d-CP for reuse, enabling the routine application of anisotropic NMR in structural analysis of small molecules. We demonstrate its efficacy by analyzing the relative stereochemistry of four compounds - estrone, santonin, griseofulvin, and cinmethylin - using anisotropic NMR data.</span></p>
},
	doi = {https://doi.org/10.1002/cmtd.202400039},
	author = {Jatheendranath, Sandesh Chickmagalur and Das, Akhi and Deshpande, Sudhindra H. and Nath, Nilamoni and Maier, Walter and Streitferdt, Verena and Marelli, Udaya Kiran}
}
