@article {49898,
	title = {Formal Synthesis of Corynanthe Indole Alkaloid ({\textpm})-Mitralactonine: Construction of α-Hydroxy-Keto Functionalized Tetracyclic Skeleton},
	journal = {Chemistryselect},
	volume = {10},
	year = {2025},
	month = {DEC },
	pages = {e04415},
	type = {Article},
	abstract = {<p>
	An efficient synthesis of a tetracyclic skeleton common to many corynanthe alkaloids was accomplished in 10 linear steps starting from a known tetrahydro beta-carboline intermediate. The tetracyclic alpha-hydroxy keto functionalized advanced precursor of (+/-)-mitralactonine was realized using Wittig olefination, ketohydroxylation of a trisubstituted alkene, and a tandem amine unmasking-intramolecular nucleophilic displacement reaction for C-N bond formation of C/D-rings.</p>
},
	keywords = {alpha-hydroxy keto, beta-carboline, corynanthe alkaloid, intramolecular N-alkylation, mitragynine},
	issn = {2365-6549},
	doi = {10.1002/slct.202504415},
	author = {Dumare, Nilesh B. and Sharma, Pallavi and Sivappa, Rasapalli and Chavan, Subhash P.}
}
