@article {49889,
	title = {Rongalite-promoted self-dimerization of 3-acylidene-2-oxindoles: a diastereoselective route to synthesis of bispirooxindoles},
	journal = {Organic \& Biomolecular Chemistry},
	volume = {23},
	year = {2025},
	month = {OCT},
	pages = {8687-8694},
	type = {Article},
	abstract = {<p>
	A facile and efficient one-pot rongalite-mediated self-dimerization of 3-acylidene-2-oxindoles has been developed for the diastereoselective synthesis of highly functionalized dispirocyclopentanebisoxindoles. The reaction proceeds via a domino sequence involving intermolecular Michael addition followed by intramolecular aldol cyclization under basic conditions. Rongalite, an inexpensive and readily available reagent (similar to\$0.03 per g), plays a crucial role in promoting the transformation, offering significant advantages such as operational simplicity, step economy, scalability to gram-scale synthesis, and potential for post-functionalization. This methodology provides an efficient route to structurally complex oxindole frameworks with high stereocontrol, demonstrating broad synthetic utility.</p>
},
	issn = {1477-0520},
	doi = {10.1039/d5ob01069a},
	author = {Chaudhari, Suryakant S. and Nichinde, Chandrakant B. and Patil, Baliram R. and Girase, Amardipsing S. and Kaulage, Sandeep H. and Kinage, Anil K.}
}
