@article {49837,
	title = {Achmatowicz rearrangement-enabled unified total syntheses of (+)-passifetilactones A-C},
	journal = {RSC Advances},
	volume = {15},
	year = {2025},
	month = {OCT},
	pages = {39919-39930},
	type = {Article},
	abstract = {<p>
	In this manuscript, we report the enantio- and diastereoselective total synthesis of three cytotoxic 2-pyrone-derived natural products passifetilactones A-C. Our strategy leverages a unified synthetic approach that originates from simple furan-based building blocks. Key transformations include the Corey-Bakshi-Shibata (CBS) reduction to access chiral furan-derived alcohol, NBS-mediated Achmatowicz rearrangement to construct the alpha-hydroxy-delta-pyrone core, followed by a highly stereoselective, iridium-catalyzed dynamic kinetic intramolecular redox isomerization to access the delta-hydroxy-alpha-pyrone framework. This streamlined route enables efficient access to passifetilactones A, B, and C in 13, 5, and 8 steps, with overall yields of 12\%, 54\%, and 37\%, respectively.</p>
},
	doi = {10.1039/d5ra06982c},
	author = {Verma, Aman Kumar and Jeddi, Dharmaraju and Kontham, Ravindar}
}
