@article {49834,
	title = {Palladium(II)-catalyzed desymmetrization of 2-alkynylbenzoate-tethered cyclohexadienones for the synthesis of polycyclic compounds},
	journal = {Organic Letters},
	volume = {27},
	year = {2025},
	month = {MAY},
	pages = {5429-5434},
	type = {Article},
	abstract = {<p>
	Pd-catalyzed cascade cyclization of 2-alkynylbenzoate-tethered cyclohexadienone was developed for the single step synthesis of isocoumarin-fused dihydrochromenones. This highly atom economical method proceeds via 6-endo-dig cyclization of tert-butyl benzoate with a tethered alkyne. By modulating the reaction solvent and metal catalyst, the methodology was diverted for the purposeful synthesis of either of the E/Z tetra-substituted alkenes.</p>
},
	issn = {1523-7060},
	doi = {10.1021/acs.orglett.5c01396},
	author = {Rai, Archana and Bajpai, Priyam and Gamidi, Rama Krishna and Vanka, Kumar and Das, Utpal}
}
