@article {49829,
	title = {Total synthesis of isatisindigoticanine H},
	journal = {Synthesis-Stuttgart},
	volume = {57},
	year = {2025},
	month = {SEP},
	pages = {2677-2682},
	type = {Article},
	abstract = {<p>
	The first total synthesis of the naturally occurring isatisindigoticanine H has been completed by employing D-mannitol as the chiral pool precursor to install the requisite stereochemistry of the natural product. Construction of the thiazole unit by dehydrative cyclization of a alpha-halo ketone with thiourea followed by Sandmeyer{\textquoteright}s reaction and subsequent nucleophilic addition of lithiated bromothiazole to the Weinreb amide are the key reactions employed in this regard.</p>
},
	keywords = {Chiral pool approach, Indothiazinone, Isatisindigoticanine H, Sandmeyer reaction, Total synthesis},
	issn = {0039-7881},
	doi = {10.1055/a-2618-0514},
	author = {Wabale, Krishna R. and Ramana, Chepuri Venkata}
}
