@article {49799,
	title = {Diastereoselective synthesis of cyclic and spirocyclic quaternary carbons via iron-catalyzed ring contraction of cyclic ketones: a formal synthesis of perhydrohistrionicotoxin},
	journal = {Organic Letters},
	volume = {27},
	year = {2025},
	month = {AUG },
	pages = {8798-8803},
	type = {Article},
	abstract = {<p>
	The iron-catalyzed hydrogen atom transfer (HAT)-initiated Dowd-Beckwith rearrangement presents a new approach for synthesizing cyclic and spirocyclic quaternary carbons from readily available beta-keto esters and cyclic diketones with high yields. This reaction proceeds in a stereocontrolled manner, enabling the formation of synthetically valuable cyclic ketones with two contiguous stereocenters, including quaternary centers. This transformation introduces an innovative bond disconnection strategy for ring-contraction reactions. Additionally, a short formal synthesis of perhydrohistrionicotoxin was efficiently achieved using this methodology.</p>
},
	issn = {1523-7060},
	doi = {10.1021/acs.orglett.5c02888},
	author = {Survase, Vijayanand U. and Rokade, Avinash D. and Handore, Kishor L.}
}
