@article {49782,
	title = {Direct synthesis of phosphine-phosphite ligand and its implication in asymmetric hydrogenation of functionalized olefins},
	journal = {Chemistryselect},
	volume = {11},
	year = {2026},
	month = {FEB },
	pages = {e07548},
	type = {Article},
	abstract = {<p>
	Phosphine-phosphite (P-OP) ligands constitute a privileged class of chiral ligands in asymmetric catalysis owing to their modular structures and tunable steric and electronic properties. Herein, we report a direct, one-pot, synthesis of a new flexible P-OP ligand (L) derived from BINOL-PCl and its in situ complexation with rhodium (Rh) for catalytic evaluation. The resulting Rh/L system efficiently hydrogenates a diverse library of 19 functionalized olefins under mild conditions, delivering moderate to excellent enantioselectivities, with ee values reaching up to 99\%. Several of the hydrogenated products correspond to valuable chiral building blocks relevant to pharmaceutical synthesis, underscoring the practical utility of flexible P-OP ligand architectures in asymmetric hydrogenation.</p>
},
	keywords = {asymmetric hydrogenation, functionalized alkene, ligand design, metal catalyzed, phosphine-phosphite},
	issn = {2365-6549},
	doi = {10.1002/slct.202507548},
	author = {Chandanshive, Amol C. and Khopade, Kishor V. and Chikkali, Samir H.}
}
