@article {49698,
	title = {Regioselective difluoroalkylation of 2-pyridones with fluoroalkyl bromides enabled by a nickel(II) catalyst},
	journal = {Chemistry-An Asian Journal},
	volume = {20},
	year = {2025},
	month = {MAY},
	type = {Article},
	abstract = {<p>
	Regioselective C-H difluoroalkylation of diverse 2-pyridones with ethyl bromodifluoroacetates and bromodifluoroacetamides is accomplished by using a (dppf)NiCl2 catalyst under mild conditions. This efficient protocol could deliver a variety of C-3 difluoroalkylated pyridones with the tolerance of a range of highly susceptible functionalities, such as -Cl, -Br, -I, -COMe, -CN, -NMe2 and -NO2, including heteroarenes like pyridinyl, furanyl, thiophenyl and carbazolyl moieties. A preliminary mechanistic study suggests the radical pathway for the reaction involving fluoroalkyl radical intermediate.</p>
},
	keywords = {2-pyridones, Difluoroalkylation, Nickel, radical intermediate, Regioselectivity},
	issn = {1861-4728},
	doi = {10.1002/asia.202401870},
	author = {Pradhan, Chandini and Khandelwal, Disha and Punji, Benudhar}
}
