@article {49502,
	title = {Accessing polysubstituted 2-cyclopentenones via base-mediated annulation of β-keto esters and phenacyl bromides},
	journal = {Organic \& Biomolecular Chemistry},
	volume = {23},
	year = {2025},
	month = {MAY},
	pages = {4519-4524},
	type = {Article},
	abstract = {<p>
	A transition metal-free method is demonstrated for the synthesis of polysubstituted 2-cyclopentenone compounds, which involves the direct annulation of phenacyl bromide with beta-keto esters in a single step. This process proceeds through a base-mediated SN2 nucleophilic substitution, followed by an intramolecular aldol condensation, resulting in the formation of three C-C bonds and one ring in a cascade manner. The experimental results achieved a record high yield of highly substituted diverse 2-cyclopentenone analogues, which exhibit very good structural resemblance to biologically significant natural compounds.</p>
},
	issn = {1477-0520},
	doi = {10.1039/d4ob02088j},
	author = {Kumar, Mohit and Paul, Vincent and Gamidi, Rama Krishna and Senthilkumar, Beeran}
}
