@article {49484,
	title = {Design and synthesis of C-α-D-mannopyranoside linked mesoporous silica nanoparticles},
	journal = {Journal of Chemical Sciences},
	volume = {137},
	year = {2025},
	month = {MAR },
	pages = {21},
	type = {Article},
	abstract = {<p>
	Mannose functionalized mesoporous silica nanoparticles (MSNs) offer a promising approach for developing more targeted, effective, and safer cancer therapies. For many of the applications, immobilization of carbohydrates like mannose onto MSNs is a crucial aspect, and in most cases, mannose moieties are connected through O-glycosidic linkages that are susceptible to acidic/enzymatic hydrolysis. To generate a stable mannose-functionalized MSN, we designed a novel C(14)-alpha-mannosylated tetradeca-1-yne. The key steps involved in the synthesis of C-mannosylated alkyne are C1-alkynylation of tri-O-acetyl-D-glucal with 1-trimethylsilyl-tetradec-1-yne, followed by stereoselective dihydroxylation and the isomerization of the internal triple bond to a terminal position. This mannose ligand was then immobilized onto azidopropyl-functionalized SBA-15 through the Cu(I)-catalyzed azide-alkyne click (CuAAC) reaction. Various physical techniques such as low-angle powder XRD, N-2 adsorption isotherms (BET), Fourier transform infrared (FTIR), high-resolution transmission electron microscopy (HRTEM), field emission scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA) have been employed to characterize this C-mannosyl SBA-15 silica matrix. We evaluated the binding ability of C-mannosyl SBA-15 nanoparticles by using fluorescein-labelled Con-A as a target protein.</p>
},
	keywords = {C-mannoside, Click reaction, mannose specific proteins, Mesoporous silica nanoparticles, Zipper reaction},
	issn = {0974-3626},
	doi = {10.1007/s12039-024-02338-7},
	author = {Nechooli, Hemanth K. and Ramtenki, Vilas and Kumar, Chepuri V. Suneel and Prasad, V. B. L. and Ramana, V. Chepuri}
}
