@article {49349,
	title = {2,3-Difunctionalization of quinones: a gold-catalyzed cascade approach for trifluoromethyl-amination or sulfoximination},
	journal = {Chemical Communications},
	volume = {60},
	year = {2024},
	month = {AUG },
	pages = {9598-9601},
	type = {Article},
	abstract = {<p>
	A one-pot domino protocol employing gold(i) catalysis has been developed for the cascade trifluoromethyl-amination/sulfoximination of quinones. Togni I serves as the trifluoromethyl installing precursor, while amine or sulfoximine serves as the aminating source. Preliminary investigations suggest a mutual activation of Togni I and the amine precursor, facilitating the facile difunctionalization of quinones with excellent regioselectivity. Extensive substrate scope exploration demonstrates moderate to good yields of difunctionalized products. Application to the natural product Juglone highlights its potential for late-stage modifications in medicinal chemistry and drug discovery. A one-pot domino protocol employing gold(i) catalysis has been developed for the cascade trifluoromethyl-amination/sulfoximination of quinones.</p>
},
	issn = {1359-7345},
	doi = {10.1039/d4cc01891e},
	author = {Sharma, Alpa and Govande, Vijaya and Mahajan, Shivangani and Sawant, Sanghapal D.}
}
