@article {49290,
	title = {Total synthesis of (-) and (+)-zingibergingerols A},
	journal = {Journal of Organic Chemistry},
	volume = {89},
	year = {2024},
	month = {OCT },
	pages = {16923-16928},
	type = {Article},
	abstract = {<p>
	The first total synthesis of both of the enantiomers of Zingibergingerol A has been accomplished. The distinctive 3,7,9-trioxabicyclo[4.2.1]nonane skeleton is crafted through gold-catalyzed alkynol cycloisomerization. The synthesis comprises sequential C-C bond formations at both ends of epichlorohydrin: first opening the epoxide with eugenol-derived alkyne, followed by subsequent epoxide installation, and again opening with a Grignard reagent. The resulting alkynol with a fixed C5 stereochemistry was subjected to O-allylation, followed by dihydroxylation and alkynol cycloisomerization.</p>
},
	issn = {0022-3263},
	doi = {10.1021/acs.joc.4c01649},
	author = {Shet, Manoj N. and Ramana, Chepuri V.}
}
