@article {49256,
	title = {The first enantioselective total synthesis of the eremophilane-type sesquiterpenoid (-)-peniroqueforin C},
	journal = {Tetrahedron Letters},
	volume = {154},
	year = {2025},
	month = {JAN },
	pages = {155386},
	type = {Article},
	abstract = {<p>
	Herein, we report the first stereoselective total synthesis of the eremophilane-type sesquiterpenoid (-)-peniroqueforin C using a chiral-pool strategy. This synthetic route features the use of readily available (S)-(+)-carvone as a chiral building block, Robinson annulation to construct the decalin system, substrate-controlled stereoselective methylation, single-step annulative construction of a tricyclic gamma-ylidene-butenolide with concomitant alkene transposition, and direct lactone-to-lactam conversion as key transformations.</p>
},
	keywords = {annulation reactions, Eremophilanes, Peniroqueforin C, Sesquiterpenoids, Total synthesis},
	issn = {0040-4039},
	doi = {10.1016/j.tetlet.2024.155386},
	author = {Ingale, Sudhir R. and Vinodkumar, Ramavath and Kontham, Ravindar}
}
