@article {49038,
	title = {Metal-free one-pot domino synthesis of oxazolidinethione derivatives of quaternary amino acids from α-amino esters and aldehydes using CS2},
	journal = {Journal of Organic Chemistry},
	volume = {89},
	year = {2024},
	month = {FEB },
	pages = {7109-7114},
	type = {Article},
	abstract = {<p>
	We present a streamlined, metal-free, one-pot domino approach to efficiently synthesize oxazolidinethione derivatives containing substituted quaternary amino acids. This method employs alpha-amino esters, aldehydes, and CS2 under mild conditions, constructing three new bonds (C-N, C-C, and C-O) to produce oxazolidinethione compounds featuring a quaternary center and a beta-hydroxy derivative in high yields. This scalable protocol enables the creation of libraries of biologically significant, intricate amino acid derivatives using amino esters and aldehydes.</p>
},
	issn = {0022-3263},
	doi = {10.1021/acs.joc.3c02217},
	author = {Shinde, Dinesh R. and Krishna, Gamidi Rama and Marelli, Udaya Kiran}
}
