@article {48906,
	title = {Review on microbial 1, 3-propanediol production: Emerging strategies, key hurdles and attainable solutions to re-establish its commercial interest},
	journal = {Industrial Crops and Products},
	volume = {209},
	year = {2024},
	month = {MAR},
	type = {Article},
	abstract = {<p>1,3-propanediol (1,3-PDO) is a vital value-added bi-functional compound that has numerous uses in the industrial sector including the polymer, pharmaceutical, food, and cosmetics industries. 1,3-PDO biosynthesis from renewable resources through green methods has received considerable attention. However, technical difficulties such as low product titer, by-product accumulation, and incomplete substrate consumption impede its sustainable production at the industrial scale. Hence, understanding the overall 1,3-PDO process development with integrated knowledge of techno-economics would help to build more production facilities across the world. In this view, the biotechnological production of 1,3-PDO is systematically reviewed briefing the synthesis routes, microbial strains, metabolic pathways, and fermentation modes along with several purification strategies. The present review also summarizes key hurdles in 1,3-PDO production and discusses the attainable solutions to achieve higher product titer. Finally, the economic viability of 1,3-PDO biosynthesis is described based on the existing research.</p>
},
	keywords = {3-Propanediol, Fermentation processes, Glycerol, Purification strategies, Techno-economical assessment},
	issn = {0926-6690},
	doi = {10.1016/j.indcrop.2023.117961},
	author = {Nimbalkar, Pranhita R. and Dharne, Mahesh S.}
}
