@article {48700,
	title = {PIDA-mediated N-N bond formation to access pyrazolidine-3,5-diones: a novel process for uricosuric agents G-25671 and sulfinpyrazone},
	journal = {Chemical Communications},
	volume = {59},
	year = {2023},
	month = {JUN },
	pages = {8242-8245},
	type = {Article},
	abstract = {<p>
	Traditionally, toxic and expensive hydrazine building blocks are required to construct pharmaceutically important pyrazolidine-3,5-diones. Herein, we have described a novel method for their synthesis based on metal-free oxidative dehydrogenative N-N bond formation by PIDA-mediated reaction of easily accessible dianilide precursors. The developed mild reaction protocol features a good functional group tolerance and scalability. The application of this method is demonstrated by offering a unique route for the synthesis of uricosuric agents G-25671 and sulfinpyrazone from inexpensive starting material aniline via smooth functionalization of the well-designed diversity-oriented cyclopropyl key intermediate.</p>
},
	issn = {1359-7345},
	doi = {10.1039/d3cc02078a},
	author = {Halder, Priyanka and Mhaske, Santosh B.}
}
