@article {48685,
	title = {BF3.Et2O-catalyzed selective C-4 alkylation of isoquinolin1(2H)-ones employing p-quinone methides},
	journal = {Chemistry-an Asian Journal},
	volume = {18},
	year = {2023},
	month = {Sep},
	type = {Article},
	abstract = {<p>
	The direct C-4 alkylation of isoquinolin-1(2H)-one moiety is a challenging transformation in organic synthesis. Here we present a practical and efficient synthesis of C-4 alkylated isoquinolin-1(2H)-ones through conjugate addition of isoquinolin-1(2H)-ones to p-quinone methides for the first time. The process is facilitated by Lewis acid catalysis and this operationally straightforward, mild, metal-free and one-pot transformation provides a wide range of C-4 alkylated isoquinolin-1(2H)ones at ambient temperature in good to excellent yields.</p>
},
	issn = {1861-4728},
	doi = {10.1002/asia.202300546},
	author = {More, Devidas A. and Ghotekar, Ganesh S. and Muthukrishnan, M.}
}
