@article {48679,
	title = {Direct amidation of acids in a screw reactor for the continuous flow synthesis of amides},
	journal = {Chemical Communications},
	volume = {59},
	year = {2023},
	month = {JUL },
	pages = {9231-9234},
	type = {Article},
	abstract = {<p>
	A simple and efficient solvent-free protocol for continuous flow synthesis of amides at room temperature is developed using easily available starting materials. N-(3-Dimethylaminopropyl)-N \&amp; PRIME;-ethylcarbodiimide hydrochloride (EDC.HCl) was used as the reagent for the formation of an amide bond without using any metal catalyst or additives. A jacketed screw reactor when operated over a residence time of 30 300 s helped achieve almost complete conversion. This approach is extended for the synthesis of 36 derivatives and 2 bioactive molecules using different substrates having different aliphatic mono and di-acids as well as aromatic acids, including aromatic hetero-acid compounds and phenyl hydrazine. The target amide was scaled up to 100 g with an average 90\% yield.</p>
},
	issn = {1359-7345},
	doi = {10.1039/d3cc02402d},
	author = {Atapalkar, Ranjit S. and Kulkarni, Amol A.}
}
