@article {48669,
	title = {Green, practical \& scalable approach towards the synthesis of valuable α-keto amides using a metal-free catalyst under solvent-free conditions},
	journal = {New Journal of Chemistry},
	volume = {47},
	year = {2023},
	month = {OCT},
	pages = {19679-19687},
	type = {Article},
	abstract = {<p>
	alpha-Ketoamides are very important motifs as they are present in many natural products, drugs \&amp; biologically important molecules. We synthesized a very simple, cheap, eco-friendly \&amp; reusable glucose-based carbonaceous material (GCM), which showed high performance as a catalyst in the oxidative cross-dehydrogenative coupling (CDC) reaction of alpha-ketoaldehydes with amines for the synthesis of alpha-ketoamides. The GCM catalyst was also very efficient for one-pot two-step synthesis of alpha-ketoamides from alpha-ketoalcohols as well. The GCM catalyst was able to catalyze alcohol oxidation in alpha-ketoalcohols followed by CDC reaction with amines to form alpha-ketoalcohols. The reactions were found to proceed smoothly at a low temperature of 50 degrees C using a green \&amp; economical metal-free catalyst under base-free, ligand-free \&amp; solvent-free reaction conditions to get the corresponding alpha-ketoamides in good to excellent yields. The results demonstrated that the GCM catalyst showed acidic as well as superior oxidising catalytic activity due to the presence of a carboxylic acid (-COOH) and hydroxyl (-OH)-enriched carbonaceous framework, which enabled the synthesis of important alpha-ketoamide motifs. The applicability of the catalyst was also evaluated for the synthesis of an anti-HIV agent drug molecule. Greener, cheaper \&amp; eco-friendly GCM catalyst as well as catalytic process for synthesis of alpha-Keto Amides.</p>
},
	issn = {1144-0546},
	doi = {10.1039/d3nj03087c},
	author = {Bankar, Shubham R. and Ghadge, Sambhaji S. and Jadhav, Vrushali H.}
}
