@article {48411,
	title = {Antibiotic natural product hunanamycin A: Lead identification towards anti-Salmonella agents},
	journal = {European Journal of Medicinal Chemistry},
	volume = {236},
	year = {2022},
	month = {JUN},
	pages = {114245},
	type = {Article},
	abstract = {<p>
	Design and synthesis of library of compounds around the antibiotic natural product hunanamycin A scaffold and their biological evaluation are disclosed here. These efforts resulted in identification of a lead compound 36, which is a structurally simplified analogue of original hunanamycin A with impressive activity against Salmonella enterica and possesses other druggable properties. In addition, no acute oral toxicity was observed for compound 36 in Swiss albino mice dosed up to 2 g/kg. It has the potential to be developed for the treatment of food infections caused by Salmonella. (c) 2022 Published by Elsevier Masson SAS.</p>
},
	keywords = {Antibiotic natural product, Hunanamycin A, Riboflavin synthase, Salmonella, Structure activity relationship},
	issn = {0223-5234},
	doi = {10.1016/j.ejmech.2022.114245},
	author = {Shingare, Rahul D. and MacMillan, John B. and Reddy, D. Srinivasa}
}
