@article {48365,
	title = {K3PO4-promoted cycloannulation of (E)-beta-Iodovinyl Sulfones with ortho-Hydroxy-chalcones/cinnamates for the synthesis of 2,3,4-trisubstituted 4h-benzopyran derivatives},
	journal = {Advanced Synthesis \& Catalysis},
	volume = {364},
	year = {2022},
	month = {DEC },
	pages = {4080-4087},
	type = {Article},
	abstract = {<p>
	K3PO4-mediated cycloannulation of (E)-beta-iodovinyl sulfones with ortho-hydroxy chalcones/ortho-hydroxy cinnamates has been realized to access 2,3,4-trisubstituted-4H-benzopyran derivatives. A metal-free tandem oxa-Michael addition and cycloannulation allows the diversity-oriented synthesis of the corresponding 3-sulfonyl-4H-benzopyrans in good to high yields. More importantly, one-pot three-component reaction between (E)-beta-iodovinyl sulfones, 2-hydroxybenzaldehydes, and phosphonium ylides has been established for the synthesis of 4H-chromene derivatives in moderate to good yields. Notably, this metal-free process features a broad substrate scope and easy elaboration into numerous multifaceted chromene products, including bioactive estrone-derivative. The present protocol is sustainable at the gram scale reactions, and post-synthetic applications were also demonstrated. A plausible mechanism is also presented on the basis of existing experimental results.</p>
},
	keywords = {(E)-beta-Iodovinyl sulfones, Benzopyrans, Cycloannulation, ortho-Hydroxy Chalcones, Sulfones},
	issn = {1615-4150},
	doi = {10.1002/adsc.202200763},
	author = {Reddy, Raju Jannapu and Kumar, Jangam Jagadesh and Krishna, Gamidi Rama}
}
