@article {48191,
	title = {Enantioselective Au(I)/Au(III) redox catalysis enabled by chiral (P,N)-ligands},
	journal = {Journal of the American Chemical Society},
	volume = {144},
	year = {2022},
	month = {APR},
	pages = {7089-7095},
	type = {Article},
	abstract = {<p>
	Presented herein is the first report of enantioselective Au(I)/Au(III) redox catalysis, enabled by a newly designed hemilabile chiral (P,N)-ligand (ChetPhos). The potential of this concept has been demonstrated by the development of enantioselective 1,2-oxyarylation and 1,2-aminoarylation of alkenes which provided direct access to the medicinally relevant 3-oxy- and 3-aminochromans (up to 88\% yield and 99\% ee). DFT studies were carried out to unravel the enantiodetermining step, which revealed that the stronger trans influence of phosphorus allows selective positioning of the substrate in the C-2-symmetric chiral environment present around nitrogen, imparting a high level of enantioselectivity.</p>
},
	issn = {0002-7863},
	doi = {10.1021/jacs.2c02799},
	author = {Chintawar, Chetan C. and Bhoyare, Vivek W. and Mane, Manoj V. and Patil, Nitin T.}
}
