@article {48039,
	title = {Poly(N-vinylcaprolactam) containing solid lipid polymer hybrid nanoparticles for controlled delivery of a hydrophilic drug gemcitabine hydrochloride},
	journal = {RSC Advances},
	volume = {12},
	year = {2022},
	month = {JUN},
	pages = {17621-17628},
	type = {Article},
	abstract = {<p>
	Folic acid tagged and hydrophilic polymer containing solid lipid nanoparticles (SLNs) were formulated for the controlled and targeted delivery of gemcitabine, a hydrophilic drug. Drug loaded SLNs were prepared by double emulsion method and optimized by 3(2) level factorial design. Then, a hydrophilic polymer, namely, poly(N-vinylcaprolactam) (PVCL) was incorporated in the optimized SLN batch in the first aqueous phase (W1) to obtain solid lipid polymer hybrid nanoparticles (SLPHNs) that were further decorated with folic acid (F-SLPHNs). TEM analysis of SLNs and SLPHNs revealed the spherical shape with no aggregation while SLPHNs showed higher \% EE. SLPHNs exhibited limited burst release of gemcitabine compared to SLNs as well as lower overall \% release. All the formulations showed good cytocompatibility against MDA-MB-231 cell lines and folic acid-tagged hybrid particles (F-SLPHNs) showed remarkably higher cellular uptake.</p>
},
	doi = {10.1039/d2ra02845j},
	author = {Surapaneni, Sai Geetika and Ambade, V. Ashootosh}
}
