@article {48006,
	title = {Rapid synthesis of the epi-biotin sulfone via tandem S,N-carbonyl migration/aza-michael/spirocyclization and haller-bauer reaction},
	journal = {ACS Omega},
	volume = {7},
	year = {2022},
	month = {MAY },
	pages = {17215-17222},
	type = {Article},
	abstract = {<p>
	A synthesis of 2-epi-biotin sulfone was accomplished from commercially available L-cysteine. The synthesis features an unprecedented tandem S,N-carbonyl migration/aza-Michael/spirocyclization reaction from an L-cysteine-derived enone with aq. ammonia, in which three new sigma bonds and two rings are formed. In addition, the synthesis includes a highly diastereoselective late-stage Haller-Bauer reaction of sulfone for direct introduction of the carbon side chain.</p>
},
	issn = {2470-1343},
	doi = {10.1021/acsomega.2c01030},
	author = {Chavan, Subhash P. and Kalbhor, Dinesh B. and Gonnade, Rajesh G.}
}
