@article {47832,
	title = {Physicochemical and in vitro antibacterial evaluation of metronidazole loaded eudragit S-100 nanofibrous mats for the intestinal drug delivery},
	journal = {Advanced Fiber Materials},
	volume = {4},
	year = {2021},
	month = {AUG},
	pages = {76-88},
	type = {Article},
	abstract = {<p>
	Metronidazole (MTZ) loaded Eudragit S-100 (ES-100) nonwoven nanofibrous mats were successfully electrospun and evaluated for intestinal drug delivery. MTZ was varied in the range of 1{\textendash}15\% (w/w) in ES-100 nanofibrous mats, the morphological characterization of nanofibrous mats was carried out using FE-SEM and the average diameter of nanofiber was found in the range 150{\textendash}600\&nbsp;nm. WAXD and DSC demonstrated the amorphous nature of MTZ in ES-100 nanofibrous mats. Their contact angle analysis confirmed the hydrophobic nature. The mechanical strength of ES-100 nanofibrous mats decreased with increasing MTZ concentration. The drug release profiles showed 74\% MTZ release from ES-100d within 2\&nbsp;h at pH 6.8 which is the colonic environment. Antibacterial activities against gram-positive bacteria (Staphylococcus aureus) and gram-negative bacteria (Escherichia coli) showed that the ES-100 nanofibrous mats loaded with MTZ exhibited good activity.</p>
},
	isbn = {2524-793X},
	doi = {10.1007/s42765-021-00090-y},
	author = {Rade, Priyanka P. and Giram, Prabhanjan S. and Shitole, Ajinkya A. and Sharma, Neeti and Garnaik, Baijayantimala}
}
