@article {47659,
	title = {Stereoselective total synthesis of (+/-)-pleurospiroketals A and B},
	journal = {Journal of Organic Chemistry},
	volume = {86},
	year = {2021},
	month = {OCT },
	pages = {13572-13582},
	type = {Article},
	abstract = {A full account of our efforts toward the stereoselective total synthesis of sesquiterpenoid-derived natural products (+/-)-pleurospiroketals A and B is described. Commercially available 3-methyl-2-cyclohexenone and 2,2-dimethyloxirane were used as key building blocks, and the substrate-controlled stereoselection was exploited to access the entire stereochemistry of these natural products. Initially, a planned synthetic route involving a [6,5]-bicyclic lactone intermediate was found to be insurmountable, and the later strategy comprising OsO4-NMO-mediated dihydroxylation of 3-methyl-2-cyclohexenone, followed by Luche reduction, Eschenmoser methylenation, and Bronsted acid-induced spiroketalization steps, was ultimately identified as the reliable strategy.},
	issn = {0022-3263},
	doi = {10.1021/acs.joc.1c01634},
	author = {Thorat, Sagar S. and Krishna, Gamidi Rama and Kontham, Ravindar}
}
