@article {47651,
	title = {Annulation of enals with carbamoylpropiolates via NHC-catalyzed enolate pathway: access to functionalized maleimides/iso-maleimides and synthesis of aspergillus FH-X-213},
	journal = {Journal of Organic Chemistry},
	volume = {86},
	year = {2021},
	month = {JUL },
	pages = {9466-9477},
	type = {Article},
	abstract = {Herein we report the N-heterocyclic carbene (NHC)-catalyzed [3 + 2] annulation of alpha,beta-unsaturated aldehydes with carbamoylpropiolates via an unusual enolate pathway leading to the construction of highly functionalized maleimides or isomaleimides. The electronic effect imposed by the alkyl/aryl group present on the amide nitrogen of carbamoylpropiolates plays a crucial role in the selective formation of these important five-membered heterocyclic building blocks. The developed protocol is mild and tolerates a wide range of substituents on both substrates. The application of this protocol in the synthesis of the antibacterial natural product Aspergillus FH-X-213 has also been demonstrated.},
	issn = {0022-3263},
	doi = {10.1021/acs.joc.1c00782},
	author = {Viveki, Amol B. and Pol, Mahesh D. and Halder, Priyanka and Sonavane, Sameer R. and Mhaske, Santosh B.}
}
