@article {47615,
	title = {Multi-step synthesis of miltefosine: integration of flow chemistry with continuous mechanochemistry},
	journal = {Chemistry-A European Journal},
	volume = {27},
	year = {2021},
	month = {DEC },
	pages = {17695-17699},
	type = {Article},
	abstract = {Herein we report for the first time, an advanced continuous flow synthesis of the blockbuster Leishmaniasis drug miltefosine from simple starting materials by a sequence involving four steps of chemical transformation including a continuous mechanochemical step. First three reaction steps were performed in simple tubular reactors in a telescopic mode, while in the last step the product precipitated from the 3(rd) step was used for a continuous mechanochemical synthesis of miltefosine. When compared to a typical batch protocol that takes 15 h, miltefosine was obtained in 58 \% overall yield in flow synthesis mode at the laboratory scale in a total residence time 34 min at synthesis rate of 10 g/hr, which is sufficient to treat 4800 patients per day.},
	keywords = {continuous flow, continuous mechanochemistry, miltefosine, multistep synthesis, reactive intermediates},
	issn = {0947-6539},
	doi = {10.1002/chem.202103499},
	author = {Patil, Niteen B. and Atapalkar, Ranjit S. and Chavan, Subhash P. and Kulkarni, Amol A.}
}
