@article {47607,
	title = {Pd(II)-catalyzed chemoselective acetoxylation of C(sp(2))-H and C(sp(3))-H bonds in tertiary amides},
	journal = {Journal of Organic Chemistry},
	volume = {86},
	year = {2021},
	month = {JUN },
	pages = {8172-8181},
	type = {Article},
	abstract = {Palladium-catalyzed chemoselective C(sp(2))-H and C(sp(3))-H acetoxylation of synthetically useful tertiary amides is reported under relatively mild reaction conditions. This protocol proceeds through the assistance of a weakly coordinated directing group (C = O) and requires low catalyst (1.0 mol \%) loading. Diverse functionalities, such as C(sp(2))-Cl, C(sp(3))-Cl, -CF3, -COOEt, and -NO2 groups, including morpholinyl, piperazinyl, and pyrrolidinyl heterocycles, are compatible under the reaction conditions. Further functionalization of this protocol is demonstrated by hydrolysis to alcohols, alcohol-acids, as well as reduction to tertiary amines. A preliminary kinetic isotope effect study supported the rate-limiting C-H bond activation process.},
	issn = {0022-3263},
	doi = {10.1021/acs.joc.1c00629},
	author = {Vijaykumar, Muniyappa and Punji, Benudhar}
}
