@article {47591,
	title = {Design and scale-up of continuous di-nitration reaction using pinched tube flow reactor},
	journal = {Journal of Flow Chemistry},
	volume = {11},
	year = {2021},
	month = {SEP},
	pages = {611-624},
	type = {Article},
	abstract = {Scale-up of the di-nitration reaction for synthesis of selective herbicide pendimethalin using only nitric acid in continuous flow is presented in this work. This work showcases an approach for smooth scale-up for an herbicide for a production capacity of 50 kg/day using a pinched tube reactor. The approach begins with the batch experiments followed by flow synthesis using a 1/8-inchSS316 helical coil tube where kinetics of the di-nitration was determined, and process optimization was done. Systematic approach was followed for quantification of heat transfer, mass transfer and residence time distribution and scale-up. Detailed scale-up methodology is presented with effect of relevant parameters for successful scale-up. Modular pilot plant with inline quenching, extraction and separation are some of the salient features presented in this work.},
	keywords = {continuous flow, nitration, Pinched tube, RTD, scale-up},
	issn = {2062-249X},
	doi = {10.1007/s41981-021-00182-1},
	author = {Hussain, Arshad and Sharma, Mrityunjay and Patil, Suneha and Acharya, Roopashree B. and Kute, Mahesh and Waghchaure, Aishwarya and Kulkarni, Amol A.}
}
