@article {47427,
	title = {Short enantioselective total synthesis of (+)-tofacitinib},
	journal = {Tetrahedron Letters},
	volume = {67},
	year = {2021},
	month = {MAR},
	pages = {152838},
	type = {Article},
	abstract = {<p>An enantioselective total synthesis of Tofacitinib (CP-690,550), a Janus tyrosine kinase (JAK3) specific inhibitor has been achieved from the readily available 4-piperidone. Proline catalysed hydroxylation is the key step for the synthesis of enantiopure 1-benzyl-4-methylpiperidin-3-ol. (C) 2021 Elsevier Ltd. All rights reserved.</p>},
	keywords = {aminohydroxylation, Hydrogenation, L-proline, piperidone},
	issn = {0040-4039},
	doi = {10.1016/j.tetlet.2021.152838},
	author = {Mane, Kishor D. and Kamble, Rohit B. and Suryavanshi, Gurunath}
}
