@article {46909,
	title = {Influence of fluorine substitution on the molecular conformation of 3 {\textquoteleft}-deoxy-3 {\textquoteleft}-fluoro-5-methyluriaine},
	journal = {Acta Crystallographica Section C-Structural Chemistry},
	volume = {76},
	year = {2020},
	month = {APR},
	pages = {346+},
	type = {Article},
	abstract = {<p>{Fluorine substitutions on the furanose ring of nucleosides are known to strongly influence the conformational properties of oligonucleotides. In order to assess the effect of fluorine on the conformation of 3{\textquoteright}-deoxy-3{\textquoteright}-fluoro-5-methyluridine (T-R(F)), C-10 H13FN2O5, we studied its stereochemistry in the crystalline state using X-ray crystallography. The compound crystallizes in the chiral orthorhombic space group P2(1)2(1)2(1) and contains two symmetry-independent molecules (A and B) in the asymmetric unit. The furanose ring in molecules A and B adopts conformations between envelope (E-2, 2{\textquoteright}-endo</p>
},
	keywords = {crystal structure, fluoro nucleoside, pseudorotation parameter, sugar puckering, uridine},
	issn = {2053-2296},
	doi = {10.1107/S2053229620003083},
	author = {Aher, Manisha N. and Erande, Namrata D. and Kumar, Vaijayanti A. and Fernandes, Moneesha and Gonnade, Rajesh G.}
}
