@article {46849,
	title = {Synthesis of 2-azabicyclo[m.n.0]-alkanes and their application towards the synthesis of strychnos and stemona classes of alkaloids},
	journal = {European Journal of Organic Chemistry},
	volume = {2020},
	year = {2020},
	month = {JUL },
	pages = {3883-3888},
	type = {Article},
	abstract = {<p>2-Azabicyclo[m.n.0]alkane ring systems, the conceptual precursors towards the synthesis of Strychnos and Stemona classes of alkaloids, were synthesized from tert-butyl 2-(phenylsulfonyl)-7-aza-bicyclo[2.2.1]hept-2-ene-7-carboxylate by alkyl Grignard reaction and intramolecular cyclisation of the in situ generated ring opening product 2. The synthesized cis-hexahydroindole 3 and cis-octahydro-benzo[b]azepine 5 scaffolds were utilized to construct the advanced intermediates 25 and 35, respectively, towards the synthesis of the corresponding Strychnos and Stemona classes of alkaloids.</p>
},
	keywords = {alkaloids, amines, Grignard reaction, Michael addition, Natural products},
	issn = {1434-193X},
	doi = {10.1002/ejoc.202000507, Early Access Date = MAY 2020},
	author = {Majumder, Binoy and Pandey, Ganesh}
}
