@article {46782,
	title = {Enantioselective synthesis of tricyclic beta-lactones by NHC-catalyzed desymmetrization of cyclic 1,3-diketones},
	journal = {Organic Letters},
	volume = {22},
	year = {2020},
	month = {JUL},
	pages = {5407-5411},
	type = {Article},
	abstract = {<p>The NHC-catalyzed desymmetrization of cyclic-1,3-diketones allowing the enantioselective construction of tricyclic beta-lactones with five contiguous stereocenters, including two quaternary stereocenters, has been developed. The mild and operationally simple addition of a-bromoenals to cyclopentane-1,3-diketone derivatives proceeds via the initial formation of chiral alpha,beta-unsaturated acylazolium intermediates and culminates in a cascade reaction, following the Michael-aldol-Iactonization pathway to deliver the beta-lactone derivatives in moderate to good yields and excellent selectivity.</p>
},
	issn = {1523-7060},
	doi = {10.1021/acs.orglett.0c01756},
	author = {Shee, Sayan and Mukherjee, Subrata and Gonnade, Rajesh G. and Biju, Akkattu T.}
}
