@article {46746,
	title = {Imines as acceptors and donors in N-heterocyclic carbene (NHC) organocatalysis},
	journal = {Chemical Communications},
	volume = {56},
	year = {2020},
	month = {AUG },
	pages = {8537-8552},
	type = {Article},
	abstract = {<p>The synthetic potential of imines as electrophiles or as a source of nucleophilic coupling partner in N-heterocyclic carbene (NHC) catalysis for the synthesis of various nitrogen heterocycles and functionalized amines is highlighted in this Feature Article. Electrophilic imines are suitable candidates for intercepting the NHC-derived acyl anions, homoenolate equivalents, and (di)enolates for the synthesis of alpha-amino ketones and a variety of lactam derivatives. Moreover, enamines generated from imines bearing alpha-hydrogen could be trapped with alpha,beta-unsaturated acylazoliums for the synthesis of functionalized dihydropyridinones. NHCs are also useful for the umpolung of imines for the generation of aza-Breslow intermediates thus leading to the synthesis of indoles, quinolines, dihydroquinoxalinesetc.A concise account of the diverse reactivity of imines in NHC catalysis has been presented.</p>
},
	issn = {1359-7345},
	doi = {10.1039/d0cc03290e},
	author = {Das, Tamal Kanti and Biju, Akkattu T.}
}
