@article {46649,
	title = {FeCl3-catalyzed oxidative decarboxylation of aryl/heteroaryl acetic acids: preparation of selected API impurities},
	journal = {Organic \& Biomolecular Chemistry},
	volume = {18},
	year = {2020},
	month = {NOV },
	pages = {8459-8466},
	type = {Article},
	abstract = {<p>There is an ever-increasing demand for impurity compounds for use in impurity profiling as regulatory agencies seek information during registration. Herein, we report the FeCl3-catalyzed oxidative decarboxylation of aryl- and heteroaryl acetic acids to the corresponding carbonyl compounds. A variety of useful aldehydes and ketones were prepared in a simple one-pot transformation by employing an environmentally benign, low-cost, and readily available iron salt. The utility of this method has been demonstrated by preparing five valuable API impurities including a multi-gram-scale synthesis of ketorolac impurity B for the first time.</p>
},
	issn = {1477-0520},
	doi = {10.1039/d0ob01790f},
	author = {Gangadurai, Chinnakuzhanthai and Illa, Giri Teja and Reddy, D. Srinivasa}
}
