@article {46436,
	title = {Formal synthesis of brivaracetam: a key to construct the pyrrolidone scaffold using Pd-catalyzed oxidative cyclization and ring-closing metathesis reaction},
	journal = {Tetrahedron Letters},
	volume = {60},
	year = {2019},
	month = {NOV},
	pages = {151249},
	type = {Article},
	abstract = {<p>A short and efficient synthetic approach for brivaracetam has been accomplished via two different routes which utilize Pd-catalyzed oxidative cyclization and ring-closing metathesis (RCM) as the key reaction. These two routes are novel, simple, scalable and rely on (E)-pent-2-en-1-ol and valeraldehyde as a commercially available starting material to yield brivaracetam with good overall yield. (C) 2019 Published by Elsevier Ltd.</p>
},
	keywords = {Antiepileptic drugs, Pd-catalyzed oxidative cyclization, pyrrolinone, Ring-closing metathesis reaction},
	issn = {0040-4039},
	doi = {10.1016/j.tetlet.2019.151249},
	author = {Chavan, Subhash P. and Kawale, Sanket A. and Chavan, Prakash N.}
}
