@article {46346,
	title = {2 {\textquoteleft}-5 {\textquoteleft}-Isomerically linked thrombin-binding aptamer (isoTBA) forms a stable unimolecular parallel G-quadruplex in the presence of Sr2+ Ions},
	journal = {ChemistrySelect},
	volume = {4},
	year = {2019},
	month = {SEP },
	pages = {10668-10673},
	type = {Article},
	abstract = {<p>The ability of the isomeri 2 {\textquoteleft}-5 {\textquoteleft}-phosphodiester-linked thrombin-binding DNA aptamer pentadecamer G(2)T(2)G(2)TGTG(2)T(2)G(2) (isoTBA), to fold into G-quadruplex structures in the presence of different mono- and divalent cations is reported. Strikingly, Sr2+ ions cause isoTBA to fold into a stable parallel unimolecular G-quadruplex, in contrast to the antiparallel unimolecular G-quadruplex fold observed in the presence of K+. IsoTBA being advantageously more stable than TBA to nuclease degradation, may thus be useful in the selective detection of Sr2+ ions, which it can sense with a detection limit of similar to 55 mu M.</p>
},
	keywords = {2 {\textquoteleft}-5 {\textquoteleft}-phosphodiester, parallel DNA G-quadruplex, strontium binding, thrombin-binding aptamer, unimolecular G-quadruplex},
	issn = {2365-6549},
	doi = {10.1002/slct.201902005},
	author = {Wagh, Atish A. and Fernandes, Moneesha}
}
