@article {46323,
	title = {Nickel-catalyzed C(2)-H arylation of indoles with aryl chlorides under neat conditions},
	journal = {Journal of Organic Chemistry},
	volume = {84},
	year = {2019},
	month = {OCT},
	pages = {12800-12808},
	type = {Article},
	abstract = {<p>Nickel-catalyzed regioselective C(2)-H arylation of indoles and pyrroles with aryl chlorides is achieved under neat conditions. This method allows the efficient coupling of diverse aryl chlorides employing a user-friendly and inexpensive Ni(OAc)(2)/dppf catalyst system at 80 degrees C. Numerous functionalities, such as halides, alkyl ether, fluoro-alkyl ether, and thioether, and substituted amines, including heteroarenes like benzothiazolyl, pyrrolyl, indolyl, and carbazolyl, are well tolerated under the reaction conditions. The preliminary mechanistic study highlights a single-electron transfer (SET) pathway for the arylation reaction.</p>
},
	issn = {0022-3263},
	doi = {10.1021/acs.joc.9b01375},
	author = {Pandey, Dilip K. and Vijaykumar, Muniyappa and Punji, Benudhar}
}
