@article {46321,
	title = {Continuous flow solvent free organic synthesis involving solids (reactants/products) using a screw reactor},
	journal = {Green Chemistry},
	volume = {21},
	year = {2019},
	month = {OCT },
	pages = {5639-5646},
	type = {Article},
	abstract = {<p>Here we report for the first-time various organic transformations such as aldol condensation, oxidation, nucleophilic substitutions, protection, acylations and coupling reactions using a mechanochemical approach at a controlled temperature using a single synthesis platform. Almost minimal solvents or solvent-free conditions are used, making it a very efficient and clean synthesis of various products. A jacketed screw reactor when operated at different temperatures (0 degrees C to 160 degrees C) and over a range of rotation speeds for changing the residence time (15 s-300 s) helped to achieve maximum conversion. This approach is also extended to the synthesis using substrates having different substitutions, heterocycles and steric hindrance.</p>
},
	issn = {1463-9262},
	doi = {10.1039/c9gc02447f},
	author = {Sharma, Brijesh M. and Atapalkar, Ranjit S. and Kulkarni, Amol A.}
}
