@article {46318,
	title = {Dimedone-based rigid organic scaffold for organizing symmetrical helical peptide chains.},
	journal = {ChemistrySelect},
	volume = {4},
	year = {2019},
	month = {OCT },
	pages = {11518-11522},
	type = {Article},
	abstract = {<p>We describe herein design, synthesis and conformational investigations of polypeptides attached on a rigid dimedone template. Two identical peptide chains are attached on a single carbon containing dimedone as a scaffold. Dimedone assists in controlling the secondary interactions through strong intramolecular helical C-12 and C-15 membered bifurcated hydrogen bonding on both the peptide chains along with propagating the helical architecture of the peptide chains attached. There exists a C-6 hydrogen bonding for the single stranded peptides attached to dimedone. Extensive structural investigations involving single crystal X-ray diffraction, solution-state NMR and CD studies of oligopeptides have been undertaken.</p>
},
	keywords = {dimedone, Helical, hydrogen bonding, Peptides, template},
	issn = {2365-6549},
	doi = {10.1002/slct.201903087},
	author = {Madica, Krishnaprasad and Lakshmi, Jerripothula K. and Madhu, Suresh and Nadimpally, Krishna Chaitanya and Gonnade, Rajesh and Jagadeesh, Bharatam and Sanjayan, Gangadhar J.}
}
