@article {46193,
	title = {Ru-catalyzed regioselective cascade annulation of acrylamides with 2-alkynoates for the synthesis of various 6-Oxo nicotinic acid esters},
	journal = {Journal of Organic Chemistry},
	volume = {84},
	year = {2019},
	month = {FEB },
	pages = {1863-1870},
	type = {Article},
	abstract = {<p>Ru-catalyzed regioselective cascade annulation of acrylamides with 2-alkynoates via aza-Michael/C-H activation sequence for the synthesis of various 6-oxo nicotinic acid esters is described. The regioselectivity of the protocol has been confirmed by performing silver mediated protodecarboxylation of the corresponding 6-oxo nicotinic acid to furnish 2-pyridone. The developed protocol is copper or silver salt-free and uses inexpensive, safe, and environmentally benign peroxide-based {\textquoteleft}{\textquoteleft}oxone{\textquoteright}{\textquoteright} as the sole oxidant. A redox-neutral version of the protocol is also demonstrated.</p>
},
	issn = {0022-3263},
	doi = {10.1021/acs.joc.8b02783},
	author = {Garad, Dnyaneshwar N. and Mhaske, Santosh B.}
}
