@article {46132,
	title = {Fe(III)-Catalyzed diastereoselective friedel-crafts alkylation-hemiketalization-lactonization cascade for the synthesis of polycyclic bridged 2-chromanol lactones},
	journal = {Organic Letters},
	volume = {21},
	year = {2019},
	month = {APR },
	pages = {2629-2633},
	type = {Article},
	abstract = {<p>An unprecedented Fe(III)-catalyzed Friedel-rafts alkylation-hemiketalization-lactonization cascade of electron-rich hydroxy arenes and distinctively functionalized unsaturated 4-keto esters is developed for the construction of polycyclic bridged 2-chromanol lactones. Following this simple and facile protocol, a broad range of products was prepared in good to excellent yields as a single diastereomer. An unusual conglomerate (enantiomerically pure polymorph) of 3ac is reported along with the absolute stereochemistry, and the remaining products were rigorously confirmed by single-crystal X-ray analysis and analogy.</p>
},
	issn = {1523-7060},
	doi = {10.1021/acs.orglett.9b00614},
	author = {Borade, Balasaheb R. and Nomula, Rajesh and Gonnade, Rajesh G. and Kontham, Ravindar}
}
