@article {45751,
	title = {Total synthesis of (+/-)-allocolchicine and its analogues using Co-catalyzed alkyne [2},
	journal = {ACS Omega},
	volume = {2},
	year = {2017},
	month = {SEP},
	pages = {5591-5600},
	type = {Article},
	abstract = {<p>The total synthesis of (+/-)-allocolchicine has been completed by employing cobalt-catalyzed alkyne [2 + 2 + 2]-cyclotrimerization as the key reaction. The essential diyne has been synthesized from easily available 3,4,5-trimethoxybenzaldehyde following simple chemical transformations. In general, the cycloaddition gave a mixture of C(9) and C(10) isomers thus allowing the synthesis of both allocolchicine and its C(10)-carboxylate. Because this cycloaddition was employed at the penultimate stage, it allowed the synthesis of various analogues having the diverse functionality at C(9) and/or C(10) of ring C.</p>},
	issn = {2470-1343},
	doi = {10.1021/acsomega.7b00980},
	author = {Paymode, Dinesh J. and Ramana, Chepuri V.}
}
